Such axon-less "neurons" (amacrine
cells) are to be found in many regions of the brain they have
certainly been found in the neuron networks of vision and smell.
In such a local network the passage of the electric signal
is done from dendrite to dendrite as a slow current that also
implies the "glia" (the substance, the cells, filling
in the space between the neurons); a true matrix of dendrites
is thus formed. According to Francis O.
Schmidt59,
these new aspects regarding the functioning of the brain could
prove to be of extreme importance in understanding the thought
processes and upper functions of the brain. It seems that such
matrices can also accommodate multiplication and division
operations60
that cannot be performed by the usual neuron networks. The "classical
" neuron networks are themselves extremely complex, each
neuron having a tri-dimensional space structure with thousands
of dendrites, with a connectivity that can give to each neuron
a specific role61;
means are there for this connectivity to be varied, depending
on the global functioning of the brain. The neuron activity depends
to a certain extend on the space-time distribution of the
influences acting upon it through
dendrites62,
thus giving the neuron also a local integrative role in relation
with these influences. (However we do not yet understand it as
psychic integrator since we cannot yet explain the way awareness
is generated.) To the complexity of neuron network and of dendrite
matrices one has to add the complexity of synapses that make the
links between neurons. The synapses connects the axon of
one neuron to the dendrite of the other. The signal can only go
one way. A neuron can have up to 10,000 such synapses. If one considers
that there are 1010 neurons in the central nervous system, then one
can count up to1014such
synapses63.
The signals are transmitted through the synapses via some chemical
messengers. The electric impulse arriving along the axon triggers
at the synapses the release of some chemical neuro-transmitters
that diffuse in the interspace between the pre- and post-synapsis
membranes. The axon does not have a particularly important
role in the variable behavior of the neuron network: it only transmits
the electric impulse. The synapses offers "element of variety
which must be the key to the nervous system", says Steven
Rose64;
at the synapses level one observes the most fragile and delicate
transmission of nervous signals. "The synapse is a type of
valve or gate. If the post-synaptic cell fired invariantly whenever
an action potential arrived down the axon from the propagating
cell, there would be no point in having a synapse. ... At the
synapses between cells lies the choice point which converts the
nervous system from a certain, predictable and dull one into an
uncertain, probabilistic and hence interesting system. Consciousness,
learning and intelligence are all
synapse-dependent"65
. The chemical averaging that the synapses performs also
rises complicated problems. They come to add to the general complexity
of the nervous system; but we can reduce only figuratively the
properties of the nervous automaton (and even more of the consciousness)
to those of the synapses. The complexity of the synapses phenomena
stems from the way the electric current releases the neuro-transmitting
chemical substances that are synthesized and stored in the vesicles;
from the nature of the mediating chemical substances (subject
to body chemistry or to some foreign substances introduced inside
the body); from the way the pre- and post-synapsis membranes
function. The works of John
Eccles66
and Bernhard Katz67
explained partly the functioning mechanism of the synapses. The
electric impulse arriving through the axon releases quanta
of the chemical mediator; this passes the pre-synapses membrane,
and then diffuses in 0.3 - 1.0 milliseconds in the interspace
(where they are vulnerable to chemical attacks) to arrive at the
post-synapsis membrane. Here it is captured by the receiving molecular
formation inside the membrane. Then either an excitation
(i.e. a depolarization of the membrane) or an inhibition
takes place; the neuro-transmitter is later destroyed by some
enzymes that turn it into inactive chemical substances. If the
synapses were to function in a strictly deterministic way, then
every electric impulse arriving from the axon would always release
the same number of chemical quanta. In reality chemical quanta
are sometimes released without an electric impulse, whereas when
the impulse is present the number of released quanta is not always
the same. Thus besides the electric impulse determination there
are fluctuation that confer to the synapses, and hence to the
neuronic subsystem, a probabilistic character, like that of a
stochastic automaton. The operation of the synapses is connected
to all the problems of cell and membrane
biology68;
of DNA and RNA, of cell energy processes (AMP and ADP); of sodium
and potassium concentration around the cell; of some neoro-transmitters
having chemical structures similar to those of hormonal substances,
thus making connection with the endocrine
system69.
The synapses mechanism has indeed an outstanding complexity, being
susceptible to the action of various agents, although we do not
yet known how it interfaces informationally with the cell andthe membrane.
It is possible that the role of the membrane
is more important in dendrites and in the body of the neuron.
If we consider the variations in the electric potential of the
liquid existing between the cells (a phenomenon related with the
ECS waves) and if we presume that some electric informational
phenomena also appear in this liquid, then surely these will interact
with the cell membrane. They can produce changes in the membrane.
Such changes take places at the level of the molecules constituting
the membrane; one does not yet know for sure, but it is believed
that these molecules take part in the informational activity of
the brain.
We have so far tried to show the extremely
complex underlayer of the nervous system. Such complexity may
appear discouraging, since biologists estimate a period of 50
to 100 years of research for breaking brain mysteries (first of
all the working of memory and of consciousness).
Regarding the neuronic organization of the
brain, it is now thought to be made up of a number of layers
of neuron networks70.
These layers are multiply connected among themselves. For example,
the sensorial structures contain layers at the level of local
excitation (for a preliminary, local analysis), then a subcortical
layer, and finally several cortical layers. There is a point to
point relationship between such levels, and hence patterns
are transmitted from a layer to an another. The brain works withpatterns
of information71.
In general there is a point-to-point relationship between points
on the body sensorial surface and the somatic sensorial cortex
(similarly between retina and the visual cortex). The light image
on the retina is to be found on the cortex (a contorted, but nevertheless
ordered image). But how does the brain further process this image?
The processing is done in a distributed
manner72,
as compatible with the received pattern of information, but
without the central control of any single organ. If the pattern
received on the visual cortex is to be used for a certain action,
say a movement, there is no executive neuron that can dictate
the way the whole system should behave. But rather, the dynamics
of the effectors, assisted by the neuronic interaction, extracts
the output path through a neuron population, each of them only
having the local information regarding the way the system is going
to behave73.
But one should notice that the distance to us reaching an integrative
and psychological explanation is still the same. Michael Arbib
developed further his model of distributed brain operation using
the holographic model of memory in a specifically nervous
form74.
According to this model the processing developed in "layers"
until the system got excited through the effectors controlling
the motor action. As an intermediate, essential stage of processing,
Arbib sees the brain using a "model" stored in memory
and then continuously corrected; both long term and short term
memories are used. According to Arbib, the long term memory is
resident in a neuron network placed between the sensorial and
the motor layers of the brain. Resulting from the interaction
between the sensorial layer and the "memory" layer there
are a number of patterns representing possible actions; they are
kept in the short period memory. The next layer takes the decision
regarding a possible course of action; the decision then passes
to the motor layer and next to the effectors. Such a model represents
a computer working in parallel with the whole pattern of information;
such model can explain the behavior of the human machine but not
the integrative character of the brain from the psychological
point of view, although it offers the possibility for integrating
the sensorial image. How is it possible for a pattern of excited
cortex points (the reflection of a retina image) to become the
continuous view observed by our mind ? Where is this process
taking place ?
Biology and Psychology in Relation with Awareness
62